姓名：张小宁
职称：副教授
个人简介：甘肃陇南人，理学博士。
专业研究领域：基础医学、生殖生物学、钙信号及lncRNA与雄性不育研究
专著与论集：
1. Jian Song, Xuhui Zeng, Xiaoning Zhang*, Yanwei Sha* and Xiuling Zhao*. Novel NLRP14 Mutations Induce Azoospermia. Andrologia. 2023
2. Ai-Wen Kang, Chi Sun, Hai-Tao Li, Kun Zhong, Xu-Hui Zeng, Zhi-Feng Gu, Bing-Qian Li, Xiao-Ning Zhang*, Jian-Lin Gao*, Tian-Xing Chen*. Puerarin extends the lifespan of Drosophila melanogaster by activating autophagy. Food Funct. 2023 Feb 21;14(4):2149-2161.
3. Shijue Dong, Chen Chen, Jiali Zhang, Yuan Gao, Xuhui Zeng*, Xiaoning Zhang*. Testicular aging, male fertility and beyond. Front Endocrinol (Lausanne). 2022 Oct 13;13:1012119.
4. Yang Zhou#, Shijue Dong#, Chen Chen, Xiaojun Liu, Xuhui Zeng, Yuan Gao*, Xiaoning Zhang*. lncRNA 1700101O22Rik and NONMMUG030480.1 Are Not Essential for Spermatogenesis in Mice. Int J Mol Sci. 2022 Aug 3;23(15):8627.
5. Hui Lin#, Peng Xiao#, Rui-Qian Bu#, Shengchao Guo#, Zhao Yang#, Daopeng Yuan#, Zhong-Liang Zhu, Chuan-Xin Zhang, Qing-Tao He, Chao Zhang, Yu-Qi Ping, Ru-Jia Zhao, Chuan-Shun Ma, Chang-Hao Liu, Xiao-Ning Zhang, Dan Jiang, Shaohui Huang, Yue-Tong Xi, Dao-Lai Zhang, Chen-Yang Xue, Bai-Sheng Yang, Jian-Yuan Li, Hao-Cheng Lin, Xu-Hui Zeng, Han Zhao，Wen-Ming Xu, Fan Yi*, Zhongmin Liu*, Jin-Peng Sun*, Xiao Yu*. Structures of the ADGRG2-Gs complex in apo and ligand-bound forms. Nat Chem Biol. 2022 Nov;18(11):1196-1203.
6. Chen Chen#, Bingqian Li#, Rongzu Huang, Shijue Dong, Yang Zhou, Jian Song, Xuhui Zeng* and Xiaoning Zhang*. Involvement of Ca2+ and ROS signals in nickel-impaired human sperm function. Ecotoxicol. Environ. Saf. 2022 Jan; 231 (2022) 113181.
7. Hang Kang, Chen Chen, Fengxin Gao, Xuhui Zeng, Xiaoning Zhang*. Expression of PPP3CC and not PPP3R2 is associated with asthenozoospermia. J. Mens Health. 2021 Sep; 17(4):183-189.
8. Yang Zhou#, Xiaona Zhang#, Suping Xiong, Xuhui Zeng*, Xiaoning Zhang*. Predicted gene 31453 (Gm31453) and the gene encoding carboxypeptidase A5 (Cpa5) are not essential for spermatogenesis and male fertility in the mouse. Reprod. Fertil. Dev.2021 Apr;33(6):401-409.
9. Xiaoning Zhang, Wenwen Zhou, Peng Zhang, Fengxin Gao, Xiuling Zhao, Winnie Waichi Shum* and Xuhui Zeng*. Cabs1 Maintains Structural Integrity of Mouse Sperm Flagella during Epididymal Transit of Sperm.Int. J. Mol. Sci. 2021 Jan 11;22(2):E652.
10. Xiaoning Zhang*, Rongzu Huang, Yang Zhou, Wenwen Zhou and Xuhui Zeng*. IP3R Channels in Male Reproduction. Int. J. Mol. Sci.2020 Dec 2;21(23):9179.
11. Xiaoning Zhang, Chen Chen, Yuanyuan Zhong, Xuhui Zeng*. lncRNA involved in triptonide-induced cytotoxicity in mouse germ cells. Reprod. Toxicol. 2020 Dec;98:218-224.
12. Xiaoning Zhang, Hang Kang, Lizhong Peng, Dandan Song, Xin Jiang, Yanting Li, Houyang Chen, Xuhui Zeng*. Pentachlorophenol inhibits CatSper function to compromise progesterone’s action on human sperm. Chemosphere. 2020 Nov;259:127493.
13. Yangyang Yuan, Xinbao Ding, Yimin Cheng, Hang Kang, Tao Luo, Xiaoning Zhang, Haibin Kuang, Ying Chen, Xuhui Zeng*, Dalei Zhang*. PFOA evokes extracellular Ca2+ influx and compromises progesterone-induced response in human sperm. Chemosphere2020 Feb;241:125074.
14. Suping Xiong, Dandan Song, Yang Xiang, Yanting Li, Yuanyuan Zhong, Hongjin Li, Peng Zhang, Wenwen Zhou, Xuhui Zeng, Xiaoning Zhang*. Reactive oxygen species, not Ca2+, mediates methotrexate-induced autophagy and apoptosis in spermatocyte cell line. Basic Clin. Pharmacol. Toxicol.2020 Feb;126(2):144-152.
15. Suping Xiong, Yanting Li, Yang Xiang, Na Peng, Chunmiao Shen, Yanqiu Cai, Dandan Song, Peng Zhang, Xiaolong Wang, Xuihui Zeng and Xiaoning Zhang*. Dysregulation of lncRNA and CircRNA Expression in Mouse Testes after Exposure to Triptolide. Curr. Drug Metab.2019;20(8):665-673.
16. Xiaoning Zhang, Peng Zhang, Dandan Song, Suping Xiong, Hongyan Zhang, Jianbo Fu, Fengxin Gao, Houyang Chen and Xuhui Zeng*. Expression profiles and characteristics of human lncRNA in normal and asthenozoospermia sperm. Biol. Reprod.2019 Apr 1;100(4):982-993.
17. Liping Zheng, Ruichen Luo, Tie Su, Liaoliao Hu, Fengxin Gao, and Xiaoning Zhang*. Differentially Expressed lncRNAs After the Activation of Primordial Follicles in Mouse. Reproductive Sciences. 2019,26:1094-1104.
18. Dejun Huang*, Xiaoning Zhang, Chen Zhang, Hui Li, Dong Li, Yan Hu, Feng Yang, Yongmei Qi. 2,4-Dichlorophenol induces DNA damage through ROS accumulation and GSH depletion in goldfish Carassius auratus. Environ. Mol. Mutagen.2018 Dec;59(9):798-804.
19. Xiaoning Zhang, Fengxin Gao, Jianbo Fu, Peng Zhang, Yuqing Wang, Xuhui Zeng*. Systematic identification and characterization of long non-coding RNAs in mouse mature sperm. PLoS One, 2017, 12(3): e0173402.
20. Fengxin Gao#, Peng Zhang#, Hongyan Zhang, Yunhui Zhang, Yunwen Zhang, Qingyun Hao, Xiaoning Zhang*. Dysregulation of long noncoding RNAs in mouse testes and spermatozoa after exposure to cadmium. Biochem. Biophys. Res. Commun. 2017; 484(2017):8-14.
21. Jianbo Fu, Xiaoning Zhang*, Peng Chen and Yingmei Zhang. Endoplasmic reticulum stress is involved in 2,4-dichlorophenol-induced hepatotoxicity. J Toxicolol Sci. 2016; 41(6):745-756.
22. Zhidan Niu, Wenya Zhang, Xueyan Gu, Xiaoning Zhang, Yongmei Qi, Yingmei Zhang*. Mitophagy inhibits proliferation by decreasing cyclooxygenase-2 (COX-2) in arsenic trioxide-treated HepG2 cells. Environ. Toxicol. Pharmacol. 2016 Jul;45:212-21.
23. Xiaoning Zhang, Xiaona Zhang, Yongmei Qi, Dejun Huang*, Yingmei Zhang*. 2,4-Dichlorophenol induces ER stress-mediated apoptosis via eIF2α dephosphorylation in vitro. Environl Toxicol. 2016.31(2):245-255.
24. Xue Wei, Yongmei Qi, Xiaoning Zhang, Xueyan Gu, Hui Cai, Jing Yang, and Yingmei Zhang*. ROS act as an upstream signal to mediate Cadmium-induced mitophagy in brain of mouse. Neurotoxicology. 2015;46C: 19-24.
25. Xue Wei, Yongmei Qi, Xiaoning Zhang, Qian Qiu, Xueyan Gu, Chen Tao, Dejun Huang, Yingmei Zhang. Cadmium induces mitophagy through ROS-mediated PINK1/Parkin pathway. Toxicol. Mech. Methods. 2014 Oct;24(7):504-11.
26. Weiwei Li, Xueyan Gu, Xiaoning Zhang, Jinxin Kong, Nan Ding, Yongmei Qi, Yingmei Zhang, Jufang Wang, Dejun Huang*. Cadmium delays non-homologous end joining(NHEJ) repair via inhibition of DNA-PKcs phosphorylation and downregulation of XRCC4 and LigaseIV. Mutat Res.2015;779:112-123.
27. Xiaoning Zhang, Xiaona Zhang, Zhidan Niu, Yongmei Qi, Dejun Huang*, Yingmei Zhang*. 2,4,6-Trichlorophenol cytotoxicity involves oxidative stress, endoplasmic reticulum stress and apoptosis. Int J Toxico. 2014;33(6):532-541.
28. Xiaoning Zhang, Hui Li, Yongmei Qi, Dejun Huang*, Yingmei Zhang*. 2,4- Dichloro -phenol induces global DNA hypermethylation through the increase of S-adenosylmethionine and the upregulation of DNMTs mRNA in the liver of goldfish Carassius auratus. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2014;160:54-59.
29. Hui Li, Xiaoning Zhang, Qian Qiu, Zhen An, Yongmei Qi, Dejun Huang*, Yingmei Zhang*. 2,4-Dichlorophenol induces apoptosis in primary hepatocytes of grass carp (Ctenopharyngodon idella) through mitochondrial pathway. Aquat. Toxicol.2013,140-141:117-122.
30. Yingxia Liu, Wenya Zhang, Xiaoning Zhang, Yongmei Qi, Dejun Huang, Yingmei Zhang*. Arsenic trioxide inhibits invasion/migration in SGC-7901 cells by activating the reactive oxygen species-dependent cyclooxygenase-2/matrix metalloproteinase-2 pathway. Expl. Bio. Med. 2011; 236: 592-597.
发明专利
1. 一种快速分离精子头、精子尾和正常有活力精子的方法（ZL 202010186121.5）
2. 一种利用精浆外泌体改善精子功能的方法（ZL 202110280768.9）
3. 一种改善精子功能的含有IDGR序列的多肽及其应用（ZL 202210210465.4）
主要科研项目
主持完成多项省部级以上科研项目，其中包括国家自然科学基金项目2项。主持在研南通市科技项目1项，参与多项国家及省部级科研项目。
讲授课程
生殖生物学及其进展、细胞信号转导
指导研究生情况
已毕业硕士生1名；在读硕士生3名。联合指导博士生1名，硕士生10人（已毕业7人）。
