姓名：毛仁芳
职称：教授
个人简介：河南鹤壁人，医学博士。
专业研究领域：基础医学、病理生理学、血管生物学、淋巴管生物学研究。
专著与论集：
1.Jiang YY, Lei GY, Lin T, et al. 1,6-Hexanediol regulates angiogenesis via suppression of cyclin A1-mediated endothelial function. BMC Biology. 2023 Apr 7;21(1):75.
2.Zhou N, Zhang Y, Lei GY, et al. Inhibition of BETs prevents heat shock-induced cell death via upregulating HSPs in SV40 large T antigen transfected cells. Genes Genomics. 2022, 44(10):1259-1269
3. Wu YY, Gu HY, Bao YH, et al.USP7 sustains an active epigenetic program via stabilizing MLL2 and WDR5 in diffuse large B-cell lymphoma. Cell Biochem Funct. 2022, 40(4):379-390.
4. Wu YC, Yang Y, Gu HY, et al. Multi-omics analysis reveals the functional transcription and potential translation of enhancers. International Journal of Cancer. 2020, 147(8)：2210-2224.
5. Zhu XL, Zhang TT, Zhang Y, et al. A Super-enhancer controls TGF- β Signaling in Pancreatic Cancer through Downregulation of TGFBR2. Cellular Signalling.2020, 66: 109470.
6. Chen H, Zhu XL, Sun R, et al. Ubiquitin-specific protease 7 is a druggable target that is essential for pancreatic cancer growth and chemoresistance. Investigational new drugs. 2020, 38(6):1707-1716.
7. Xu YP, Wu YC, Zhang SL et al. A tumor specific super-enhancer drives immune evasion by guiding synchronous expression of PD-L1 and PD-L2. Cell Reports. 2019,29(11): 3435-3447.
8. Wu YC, Tao BR, Zhang TY et al. Pan-cancer analysis reveals disrupted circadian clock associates with T cell exhaustion. Frontiers in Immunology. 2019, 10: 2451.
9. Mao RF, Wu YC, Ming Y et al. Enhancer RNAs: a missing regulatory layer in gene transcription. Sci China Life Sci. 2019, 62(7):905-912.
10. Mao RF, Meng S, Gu QL et al. AIBP limits angiogenesis through r-secretase-mediated upregulation of Notch Signaling.Circulation Research, 2017,120: 1727-1739.
11. Mao RF, Yang RY, Chen X et al. Regnase-1, a rapid response ribonuclease regulating inflammation and conquering challenges. Cellular and Molecular Immunology.2017, 14, 412-422.
12. Mao RF, Rubio V, Chen HR et al. OLA1 protects cells in heat shock by stabilizing HSP70. Cell Death and Disease, 2013, 4: e491.
13. Mao RF, Fan YH, Fu SB et al. TAK1 lysine 158 is required for TGF-β-induced TRAF6-mediated Smad-independent IKK/NF-κB and JNK/AP-1 activation. Cellular Signalling, 2011,23(1): 222-227.
14. Mao RF, Fan YH, Fu SB. Association study between methylenetetrahydrofolate reductase gene polymorphisms and Graves’ disease. Cell Biochemistry and Function, 2010,28(7): 585-590
15. Mao RF, Fan YH, Jin Y et al. Methylenetetrahydrofolate reductase gene polymorphisms and lung cancer: a meta-analysis. Journal of Human Genetics, 2008, 53(4): 340-348.
16. Mao RF, Fan YH, Chen F et al. Methylenetetrahydrofolate reductase gene polymorphisms in 13 Chinese populations. Cell Biochemistry and Function, 2008, 26(3): 352-358.
17. Mao RF, Fan YH, Chen F et al. GeneticpolymorphismofMTHFR G1793A in Chinese populations. European Journal of Epidemiology, 2008,23(5): 363-368.
主要科研项目
主持多项省部级以上科研项目，其中包括国家自然科学基金项目3项，江苏省自然科学基金1项，江苏省特聘教授基金，美国AHA博士后基金。
讲授课程
病理生理学，细胞生物学，科研思维案例教学，高级病理生理学，病理生理学研究进展
指导研究生情况
已毕业硕士生7名（包括联合培养3名）；在读博士生2名，硕士生6名。
